Introduction: Despite availability of approved oral antivirals like nirmatrelvir/ritonavir to treat COVID-19 in high-income countries since 2021, access to these drugs remains largely unavailable across the African continent.Ghana, Malawi, Rwanda and Zambia, all members of the COVID Treatment QuickStart Consortium, leveraged existing infrastructure
Epithelial-to-mesenchymal transition (EMT) in cancer cells facilitates tumor progression by promoting invasion and metastasis.Snail is a transcriptional factor PEA PROTEIN that induces EMT, while P-glycoprotein (P-gp) is an efflux transporter involved in anticancer drug resistance, and P-gp efflux activity is stimulated in Snail-overexpressing lung
The forces that arise from the actin cytoskeleton play a crucial role in determining the cell shape.These include protrusive forces due to actin polymerization and adhesion to the external matrix.We present here a theoretical model for the cellular shapes resulting from the feedback between the membrane shape and the forces acting on the membrane,
Fuzzy sets play a crucial role in representing real-world complexities where precise binary logic falls short.Rough sets are closely related to fuzzy sets, and their combined use provides a powerful framework for handling uncertain and incomplete information.The Heat Sink combination of rough sets and fuzzy sets is an intriguing area of research th